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MDA-19 is a cannabinoid receptor agonist that acts as a powerful and selective CB2 agonist, with significant selectivity over the psychoactive CB1 receptor. There is, however, some variation between species. Although it was effective in treating neuropathic pain in animals, it did not produce cannabis-like behavioral effects. ChemsPowder has MDA-19 for sale at the most competitive prices. Order MDA-19 online and receive it within a few days!

What are the characteristics of MDA-19?

MDA19 had a 4-fold higher affinity for the human CB (2) receptor compared to the human CB1 receptor (K(i) = 43.3 +/- 10.3 vs 162.4 +/- 7.6 nM) and a roughly 70-fold higher affinity for the rat CB2 receptor compared to the rat CB1 receptor (K(i) = 16.3 +/- 2.1 vs 1130 +/- 574 nM). Chemspowder

In guanosine triphosphate (GTP)gamma [(35) S] functional tests, MDA19 acted as an agonist at the human CB1 and CB2 receptors, as well as the rat CB1 receptor, but as an inverse agonist at the rat CB2 receptor. Buy MDA-19 Online

In 3′,5′-cyclic adenosine monophosphate (cAMP) tests, MDA19 acted as an agonist at the rat CB1 receptor but had no functional action at the rat CB (2) receptor. Extracellular signal-regulated kinase 1 and 2 activation tests

In rats, MDA19 acted as an agonist at the CB2 receptor. MDA19 reduced tactile allodynia caused by spinal nerve ligation or paclitaxel in rats and CB2(+/+) mice in a dose-dependent manner, but not in CB2(-/-) mice, indicating that MDA19 was mediated by CB2 receptors. MDA19 had no effect on the locomotion of rats. Buy MDA-19 Online

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